Condensed heterocyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsSatoshi Yamamoto, Junya Shirai, Yoshiyuki Fukase, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Kazuko Yonemori, Hideyuki Nakagawa
Life of this patent
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Abstract
The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.
Claims13
A compound represented by the formula (I′):
- wherein
- R1A is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon-oxy group,
- R2A and R3A are each independently a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydrocarbon-oxy group, an acyl group, a halogen atom, a cyano group, an optionally substituted hydrocarbon-amino group, an optionally substituted hydrocarbon-sulfanyl group, an optionally substituted hydrocarbon-sulfenyl group, an optionally substituted hydrocarbon-sulfonyl group or a nitro group, or R2A and R3A optionally form, together with the carbon atoms which they are bonded to, an optionally substituted hydrocarbon ring,
- R5A is a hydrogen atom or a halogen atom,
- Q′ is a bivalent group selected from
- wherein
- [A1] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group, a phenyl group and an optionally substituted C1-6 alkyl group, wherein the two substituents bonded to the single carbon atom are optionally combined to each other to form a hydrocarbon ring, and [A2] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group and an optionally substituted C1-6 alkyl group, wherein the two substituents bonded to the single carbon atom are optionally combined to each other to form a hydrocarbon ring, or the methylene group in [A1] or [A2] is optionally combined to the substituent on the adjacent methylene group to form an optionally substituted hydrocarbon ring,
- R4A and R4B are the same or different and each is an optionally substituted hydrocarbon group,
- X′ is an oxygen atom, a sulfur atom, or an imino group having an optionally substituted hydrocarbon group or a hydrogen atom,
- n is an integer of 1 to 5,
- n′ is an integer of 1 to 4,
- n″ is an integer of 1 to 3, and
- x′ and y′ are each 0 or natural number, and the sum is 0 to 4, and
- Ring B′ is a benzene ring optionally having additional substituent(s), or a pyridine ring optionally having additional substituent(s), provided that when R5A is a halogen atom, then Ring B′ is a benzene ring optionally having additional substituent(s), provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded,
- or a salt thereof.
N-(4-Cyanophenyl)-N′-(9-ethyl-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-3-methylpentanediamide or a salt thereof.
N-(3-Chloro-4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide or a salt thereof.
N-{4-[(3-Chloro-4-cyanophenyl)amino]-2-methyl-4-oxobutyl}-9-ethyl-9H-carbazole-3-carboxamide or a salt thereof.
A medicament comprising a compound represented by the formula (I′):
- wherein
- R1A is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon-oxy group,
- R2A and R3A are each independently a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydrocarbon-oxy group, an acyl group, a halogen atom, a cyano group, an optionally substituted hydrocarbon-amino group, an optionally substituted hydrocarbon-sulfanyl group, an optionally substituted hydrocarbon-sulfenyl group, an optionally substituted hydrocarbon-sulfonyl group or a nitro group, or R2A and R3A optionally form, together with the carbon atoms which they are bonded to, an optionally substituted hydrocarbon ring,
- R5A is a hydrogen atom or a halogen atom,
- Q′ is a bivalent group selected from
- wherein
- [A1] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group, a phenyl group and an optionally substituted C1-6 alkyl group, wherein the two substituents bonded to the single carbon atom are optionally combined to each other to form a hydrocarbon ring, and [A2] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group and an optionally substituted C1-6 alkyl group, wherein the two substituents bonded to the single carbon atom are optionally combined to each other to form a hydrocarbon ring, or the methylene group in [A1] or [A2] is optionally combined to the substituent on the adjacent methylene group to form an optionally substituted hydrocarbon ring,
- R4A and R4B are the same or different and each is an optionally substituted hydrocarbon group,
- X′ is an oxygen atom, a sulfur atom, or an imino group having an optionally substituted hydrocarbon group or a hydrogen atom,
- n is an integer of 1 to 5,
- n′ is an integer of 1 to 4,
- n″ is an integer of 1 to 3, and
- x′ and y′ are each 0 or natural number, and the sum is 0 to 4, and
- Ring B′ is a benzene ring optionally having additional substituent(s), or a pyridine ring optionally having additional substituent(s), provided that when R5A is a halogen atom, then Ring B′ is a benzene ring optionally having additional substituent(s),
- or a salt thereof.
13-14. (canceled)
Dependencies are inferred from the claim text.