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US 2014/0228406 A1Published application
Fentanyl derivatives as ph-dependent opioid receptor agonists
AssigneesKonrad-Zuse-Institut, Charite-Universitatsmedizin Berlin
InventorsChristoph Stein, Marcus Weber, Christian Zöllner, Olga Scharkoi
Life of this patent
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Abstract
The invention relates to fluorinated fentanyl derivatives that function as opioid receptor agonists, which activate target opioid receptors in a pH-dependent manner, and are thus selective for the receptors in inflamed (acidic) milieu; uses thereof and pharmaceutical compositions comprising them.
Claims20
Compound of the general Formula I
- whereby at least one of R1, R2, R3, R4 is F, and
- the remaining residues at positions R1, R2, R3, R4 are H.
(canceled)
Dependencies are inferred from the claim text.