Compositions and methods for treating diseases of the nail
AssigneeDow Pharmaceutical Sciences, Inc.
InventorsGareth Winckle, Gregory T. Fieldson
Life of this patent
Estimating the term…
Abstract
Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.
Claims28
-24. (canceled)
A pharmaceutical composition for the topical treatment of a disorder of the nail or nail bed comprising a volatile alcohol, a volatile silicone, an anti-oxidant, one or more esters of the formula RCO—OR′, wherein R and R′ may be identical or different and each of R and R′ represents a linear or branched chain of an alkyl, alkenyl, alkoxycarbonylalkyl, or alkoxycarbonyloxyalkyl radical having from 1 to 25 carbon atoms, and wherein the chain of R′ is at least 5 carbons, and a triazole antifungal agent, wherein the volatile silicone is present in the composition at a concentration less than 25% w/w, wherein the composition does not form a solid film when topically applied to the surface of a nail, and wherein the surface tension of the composition is 40 dynes/cm or less.
-33. (canceled)
-43. (canceled)
A pharmaceutical composition for the topical treatment of a disorder of the nail or nail bed comprising a volatile alcohol, a volatile silicone, an anti-oxidant, one or more esters of the formula RCO—OR′, wherein R and R′ may be identical or different and each of R and R′ represents a linear or branched chain of an alkyl, alkenyl, alkoxycarbonylalkyl, or alkoxycarbonyloxyalkyl radical having from 1 to 25 carbon atoms, and wherein the chain of R′ is at least 5 carbons, and a triazole antifungal agent, wherein the ratio of alcohol to volatile silicone in the composition % w/w is at least 2:3, wherein the composition does not form a solid film when topically applied to the surface of a nail and wherein the surface tension of the composition is 40 dynes/cm or less.
-56. (canceled)
-63. (canceled)
Dependencies are inferred from the claim text.