Disubstituted 5-fluoro-pyrimidines

A compound of general formula (I)

• wherein
• R1 represents a group selected from C1-C6-alkyl-, C3-C7-cycloalkyl heterocyclyl-, phenyl, heteroraryl, phenyl-C1-C3-alkyl- or heteroaryl-C1-C3-alkyl-, wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of hydroxy, cyano, halogen, halo-C1-C3-alkyl-, C1-C6-alkoxy-, C1-C3-fluoroalkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines;
• R2 represents a group selected from
• R3, R4 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
• R5 represents a group selected from
• a) a C1-C6-alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl, wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
• b) a C3-C7-cycloalkyl- group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-;
• c) a heterocyclyl- group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-;
• d) a phenyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
• e) a heteroaryl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
• f) a phenyl-C1-C3-alkyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
• g) a heteroaryl-C1-C3-alkyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
• h) a C3-C6-cycloalkyl-C1-C3-alkyl- group, which C3-C6-cycloalkyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
• i) a heterocyclyl-C1-C3-alkyl- group, which heterocyclyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
• j) phenyl-cyclopropyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
• k) a heteroaryl-cyclopropyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
• R6, R7 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
• or its salts, solvates or salts of solvates.