Methylpiperidine derivative
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsMasahito Abe, Aya Futamura, Ryo Suzuki, Dai Nozawa, Hiroshi Ohta, Yuko Araki
Life of this patent
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Abstract
A compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which acts relying on an orexin (OX) receptor antagonistic activity and is useful for the treatment or prevention of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, head ache, migraine, pain, gastrointestinal diseases, epilepsy, inflammations, immune-related diseases, endocrine-related diseases and hypertension.
Claims12
A methylpiperidine derivative represented by formula (IA):
- wherein
- X represents a nitrogen atom or a formula CH;
- Y represents a nitrogen atom or a formula CH;
- R1 represents a hydrogen atom, a halogen atom, a cyano group, a C1-6 alkyl group (wherein the C1-6 alkyl group may be substituted with 1 to 3 halogen atoms), or a C1-6 alkoxy group;
- R2 represents a heteroaryl group (wherein the heteroaryl group may be substituted with 1 to 3 identical or different substituents selected from the group consisting of a halogen atom and a C1-6 alkoxy group);
- and
- R3 and R4 are the same or different and each represent a hydrogen atom, a halogen atom, a cyano group, a C1-6 alkyl group, or a C1-6 alkoxy group (wherein the C1-6 alkyl group and the C1-6 alkoxy group may each be substituted with 1 to 3 halogen atoms)
- or a pharmaceutically acceptable salt thereof.
A methylpiperidine derivative represented by formula (I):
- wherein
- X represents a nitrogen atom or a formula CH;
- R1 represents a hydrogen atom, a halogen atom, or a C1-6 alkyl group;
- R2 represents a heteroaryl group, wherein the heteroaryl group may be substituted with 1 to 3 halogen atoms;
- and
- R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group (wherein the C1-6 alkyl group and the C1-6 alkoxy group may each be substituted with 1 to 3 halogen atoms)
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.