Microbiocidal pyrazole derivatives

A compound of formula I:

• wherein
• G1, G2 and G3 are independently O or S;
• T is CR13 or N;
• Y1 and Y2 are independently CR14 or N;
• n is 1 or 2;
• p is 1 or 2, providing that when n is 2, p is 1;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R13 and R14 each independently are hydrogen, halogen, cyano, C1-C4alkyl, C3-C5cycloalkyl or C1-C4haloalkyl;
• R11 is hydrogen, C1-C4alkyl, C3-C5cycloalkyl or C1-C4alkoxy;
• R12 is aryl optionally substituted by one or more R15, arylalkyl optionally substituted by one or more R15, a 7- to 11-membered isocyclic ring system optionally substituted by one or more R16, wherein the isocyclic ring system contains at least one aromatic cycle, heteroaryl optionally substituted by one or more R15, heteroarylalkyl optionally substituted by one or more R15, a 7- to 11-membered heterocyclic ring system optionally substituted by one or more R16, or group C-1
• each R15 independently is halogen, cyano, amino, nitro, hydroxyl, mercapto, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C4alkyl, C3-C8cycloalkyl-C1-C4alkyloxy, C3-C8cycloalkyl-C1-C4alkylthio, C1-C8alkoxy, C3-C8cycloalkyloxy, C1-C8alkenyloxy, C2-C8alkynyloxy, C1-C8alkylthio, C1-C8alkylsulfonyl, C1-C8alkylsulfinyl, C3-C8cycloalkylthio, C3-C8cycloalkylsulfonyl, C3-C8cycloalkylsulfinyl, aryl, aryloxy, arylthio, arylsulfonyl, arylsulfinyl, aryl-C1-C4alkyl, aryl-C1-C4alkyloxy, aryl-C1-C4alkylthio, heterocyclyl, heterocyclyl-C1-C4alkyl, heterocyclyl-C1-C4alkyloxy, heterocyclyl-C1-C4alkylthio, NH(C1-C8alkyl), N(C1-C8alkyl)2, C1-C4alkylcarbonyl, C3-C8cycloalkylcarbonyl, C2-C8alkenylcarbonyl, C2-C8alkynylcarbonyl, C1-C4alkylcarboxy, C3-C8cycloalkylcarboxy, C2-C8alkenylcarboxy, C2-C8alkynylcarboxy, wherein alkyl, alkenyl, alkynyl, and cycloalkyl are optionally substituted by halogen, and wherein aryl and heterocyclyl are optionally substituted by one or more R17;
• each R16 independently is halogen, cyano, amino, nitro, hydroxyl, oxo, mercapto, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C4alkyl, C3-C8cycloalkyl-C1-C4alkyloxy, C3-C8cycloalkyl-C1-C4alkylthio, C1-C8alkoxy, C3-C8cycloalkyloxy, C1-C8alkenyloxy, C2-C8alkynyloxy, C1-C8alkylthio, C1-C8alkylsulfonyl, C1-C8alkylsulfinyl, C3-C8cycloalkylthio, C3-C8cycloalkylsulfonyl, C3-C8cycloalkylsulfinyl, aryl, aryloxy, arylthio, arylsulfonyl, arylsulfinyl, aryl-C1-C4alkyl, aryl-C1-C4alkyloxy, aryl-C1-C4alkylthio, heterocyclyl, heterocyclyl-C1-C4alkyl, heterocyclyl-C1-C4alkyloxy, heterocyclyl-C1-C4alkylthio, NH(C1-C8alkyl), N(C1-C8alkyl)2, C1-C4alkylcarbonyl, C3-C8cycloalkylcarbonyl, C2-C8alkenylcarbonyl, C2-C8alkynylcarbonyl, C1-C4alkylcarboxy, C3-C8cycloalkylcarboxy, C2-C8alkenylcarboxy, C2-C8alkynylcarboxy, wherein alkyl, alkenyl, alkynyl and cycloalkyl are optionally substituted by halogen, and wherein aryl and heterocyclyl are optionally substituted by one or more R17;
• each R17 independently is halogen, cyano, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy;
• A is C(R25R26), C(═O), C(═S), NR31, O or S;
• Q1 is C(R27R28), C(═O), C(═S), NR31, O or S;
• Q2 is C(R29R30), C(═O), C(═S), NR31, O or S;
• R22 is hydroxyl, O−M+, OC(═O)R35, amino or NHR32;
• x is 0 or 1, providing that when x is 1, Q1 and Q2 cannot both be oxygen;
• M+ is a metal cation or ammonium cation;
• R25, R26 R27, R28, R29 and R30 each independently are hydrogen, halogen, hydroxyl, amino, cyano, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C8cycloalkyl, C1-C8alkoxy, C1-C8alkylthio, C1-C8alkylsulfonyl, C1-C8alkylsulfinyl, aryl, heteroaryl or NHR22, wherein alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl are optionally substituted by one or more R33;
• and wherein
• R25 and R26, R27 and R28, and/or R29 and R30 may together form a saturated three- to six-membered alicyclic or heterocyclic ring wherein the aliyclic and heterocyclic rings are optionally substituted by one or more R34;
• and/or
• R25 and R27, and/or R28 and R29 may together form a saturated or partially unsaturated four- to seven-membered alicyclic or heterocyclic ring wherein the aliyclic and heterocyclic rings are optionally substituted by one or more R34;
• and/or
• R25 and R29 may together form a saturated or partially unsaturated four- to seven-membered alicyclic or heterocyclic ring wherein the aliyclic and heterocyclic rings are optionally substituted by one or more R34;
• R31 and R32 each independently are hydrogen, C1-C8alkyl, C1-C8haloalkyl C2-C8alkenyl, C1-C8haloalkenyl C2-C8alkynyl, C2-C8haloalkynyl, C3-C8cycloalkyl, C3-C8halocycloalkyl, C1-C8alkoxy, C1-C8haloalkoxy, C1-C8alkylcarbonyl, C1-C8haloalkylcarbonyl, C1-C8alkylsulfonyl, C1-C8haloalkylsulfonyl, amino, NH(C1-C8alkyl), N(C1-C8alkyl)2, aryl or heterocyclyl, wherein aryl and heterocyclyl are optionally substituted by one or more R34;
• each R33 independently is halogen, cyano, amino, nitro, hydroxyl, mercapto, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C4alkyl, C3-C8cycloalkyl-C1-C4alkyloxy, C3-C8cycloalkyl-C1-C4alkylthio, C1-C8alkoxy, C3-C8cycloalkyloxy, C1-C8alkenyloxy, C2-C8alkynyloxy, C1-C8alkylthio, C1-C8alkylsulfonyl, C1-C8alkylsulfinyl, C3-C8cycloalkylthio, C3-C8cycloalkylsulfonyl, C3-C8cycloalkylsulfinyl, aryl, aryloxy, arylthio, arylsulfonyl, arylsulfinyl, aryl-C1-C4alkyl, aryl-C1-C4alkyloxy, aryl-C1-C4alkylthio, heterocyclyl, heterocyclyl-C1-C4alkyl, heterocyclyl-C1-C4alkyloxy, heterocyclyl-C1-C4alkylthio, NH(C1-C8alkyl), N(C1-C8alkyl)2, C1-C4alkylcarbonyl, C3-C8cycloalkylcarbonyl, C2-C8alkenylcarbonyl, C2-C8alkynylcarbonyl, wherein alkyl, alkenyl, alkynyl and cycloalkyl are optionally substituted by halogen, and wherein aryl and heterocyclyl are optionally substituted by one or more R34;
• each R34 independently is halogen, cyano, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy;
• and
• R35 is C1-C6alkyl, C1-C6alkoxy or C1-C6alkylcarboxy;
• or a salt or a N-oxide thereof.