Substituted imidazopyridazines

A compound of general formula (I):

• in which:
• Q represents a group selected from:
• wherein * indicates the point of attachment of said groups with the rest of the molecule;
• represents a group selected from:
• wherein * indicates the point of attachment of said groups with the rest of the molecule;
• R1 represents a linear C2-C6-alkyl-, a branched C3-C6-alkyl-, or a C3-C6-cycloalkyl group which is optionally substituted with one or more substituents selected, independently from each other, from:
• a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-;
• aryl-optionally substituted one or more times, independently from each other, with an R substituent;
• heteroaryl-optionally substituted one or more times, independently from each other, with an R substituent;
• —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OH, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —OH, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S— group;
• R2 represents a C1-C6-alkyl-;
• halo-C1-C6-alkyl-;
• phenyl-optionally substituted one or more times, independently from each other, with an R substituent;
• 5- or 6-membered heteroaryl-optionally substituted one or more times, independently from each other, with an R substituent;
• R3 represents a substituent selected from:
• a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-haloalkoxy-, —OC(═O)R′, —SH, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group;
• R4 represents a substituent selected from:
• a hydrogen atom, a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-optionally substituted one or more times, independently from each other, with an R substituent;
• heteroaryl-optionally substituted one or more times, independently from each other, with an R substituent;
• —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group;
• R represents a substituent selected from:
• a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″group;
• R′ and R″ represent, independently from each other, a substituent selected from:
• C1-C6-alkyl-, C1-C6-haloalkyl-;
• n represents an integer of 0, 1, 2 or 3;
• or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.