Heteroaryl-substituted pyrazolopyridines and use thereof as soluble guanylate cyclase stimulators

A compound of formula (I)

• wherein
• A represents nitrogen or CR3,
• where
• R3 represents hydrogen, deuterium, halogen, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, cyclopropyl, cyclobutyl, hydroxy, amino, phenyl or 5- or 6-membered heteroaryl,
• in which (C1-C4)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, cyclopropyl and cyclobutyl,
• L represents a *—CR4AR4B—(CR5AR5B)p—# group,
• where
• * represents the point of attachment to the carbonyl group,
• # represents the point of attachment to the pyrimidine ring or triazine ring,
• p represents a number 0, 1 or 2,
• R4A represents hydrogen, fluorine, (C1-C4)-alkyl, hydroxy or amino,
• in which (C1-C4)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and amino,
• R4B represents hydrogen, fluorine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C1-C4)-alkoxycarbonylamino, cyano, (C3-C7)-cycloalkyl, difluoromethoxy, trifluoromethoxy, phenyl or a group of the formula -M-R8,
• in which (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, cyano, trifluoromethyl, (C3-C7)-cycloalkyl, hydroxy, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and amino,
• and in which
• M represents a bond or (C1-C4)-alkanediyl,
• R8 represents —(C═O)n—OR9, —(C═O)r—NR9R10, —C(═S)—NR9R10, —NR9—(C═O)—R12, —NR9—(C═O)—NR10R11, —NR9—SO2—NR10R11, —NR9—SO2—R12, —S(O)s—R12, —SO2—NR9R10, 4- to 7-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl,
• in which
• r represents the number 0 or 1,
• s represents the number 0, 1 or 2,
• R9, R10 and R11 independently of one another each represent hydrogen, (C1-C6)-alkyl, (C3-C8)-cycloalkyl, 4- to 7-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl,
• or
• R9 and R10 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle,
• in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,
• or
• R10 and R11 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle,
• in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,
• R12 represents (C1-C6)-alkyl or (C3-C7)-cycloalkyl,
• or
• R9 and R12 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle,
• in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,
• and
• in which 4- to 7-membered heterocyclyl, phenyl and 5- or 6-membered heteroaryl for their part may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, oxo, thioxo and (C1-C4)-alkoxy,
• and
• in which the aforementioned (C1-C4)-alkyl, (C1-C6)-alkyl, (C3-C8)-cycloalkyl and 4- to 7-membered heterocyclyl groups, unless stated otherwise, may each independently of one another additionally be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl, amino, phenyl, 4- to 7-membered heterocyclyl and 5- or 6-membered heteroaryl,
• or
• R4A and R4B together with the carbon atom to which they are attached form a (C2-C4)-alkenyl group, an oxo group, a 3- to 6-membered carbocycle or a 4- to 7-membered heterocycle,
• in which the 3- to 6-membered carbocycle and the 4- to 7-membered heterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C1-C4)-alkyl,
• R5A represents hydrogen, fluorine, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl or hydroxy,
• R5B represents hydrogen, fluorine, (C1-C4)-alkyl or trifluoromethyl,
• R1 represents hydrogen, halogen, cyano, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl or (C3-C7)-cycloalkyl,
• R2 represents 5- or 6-membered heteroaryl,
• where 5- and 6-membered heteroaryl may be substituted by 1 or 2 fluorine substituents,
• R6 represents hydrogen, cyano, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl or (C3-C7)-cycloalkyl,
• R7 represents hydrogen, cyano, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl or (C3-C7)-cycloalkyl,
• or an N-oxide, salt, or a salt of the N-oxide thereof.