Novel compounds as hif-1alphainhibitors and manufacturing process thereof

A preparation method of a compound of Formula I comprising a step of which a compound of Formula 2 as a start substance reacts with a compound of Formula 3,1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI), 1-Hydroxybenzotriazole hydrate (HOBt) and N,N-diisopropylethylamine (DIPEA) by coupling reaction in dimethylformamide (DMF),

• wherein,
• R1 represents hydrogen, methyl, fluoro or chloro;
• R2 represents hydrogen or methyl;
• R3 represents,
• wherein,
• Ra represents dimethyl, cyclopropyl, N,N-dimethylaminoethyl or 2-furanylmethyl;
• Rb represents hydrogen, (S)-methyl or (R)-methyl;
• Rc represents methyl, isopropyl, tert-butoxycarbonyl(Boc), 4-trifluoromethylbenzyl, hydroxyethyl or propynyl;
• and
• Rd represents
• Re represents hydrogen or hydroxyl;
• and
• n represents 1, 2 or 3.