5,7-substituted-imidazo[1,2-c]pyrimidines

A compound of the general Formula I

• and stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein:
• X1 is N or CR3b;
• X2 is N or CR3a;
• R1 is hetAr1, hetAr2, hetAr3, Ar1, Ar2, (3-6C)cycloalkyl or N-(1-3C alkyl)pyridinonyl;
• hetAr1 is a 5 membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, O and S and optionally substituted with one or more substituents independently selected from halogen, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, (1-4C alkoxy)(1-6C)alkyl, trimethylsilyl(1-4C alkoxy)(1-6C)alkyl, (3-6C)cycloalkyl, a 4-6 membered oxacyclic ring, hetCyca(1-2C)alkyl, hetAra(1-2C)alkyl and (1-4C alkylsulfonyl)(1-6C alkyl);
• hetCyca is a 6 membered heterocycle having 1-2 ring heteroatoms independently selected from N and O and is optionally substituted with (1-6C)alkyl;
• hetAra is a 6 membered heteroaryl having 1-2 ring nitrogen atoms;
• hetAr2 is a 9-membered bicyclic partially unsaturated or fully unsaturated heterocyclic ring having 3 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• hetAr3 is a 6 membered heteroaryl having 1-2 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl, hetCycb and (1-6C)alkoxy;
• hetCycb is a 6-membered heterocycle having 1-2 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• Ar1 is phenyl substituted with a substituent selected from halogen, hetCycc, hetCycd, hetArb, trifluoro(1-6C)alkyl and (1-6C)alkoxy;
• hetCycc is a 6 membered heterocycle having 1-2 ring heteroatoms independently selected from N and O and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• hetCycd is an 8-membered bridged heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O;
• hetArb is a 5-membered heteroaryl ring having 1-2 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• Ar2 is a benzo ring fused to a 5-6 membered azacyclic ring and is optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• R2 is hydrogen, halogen, (1-4C)alkyl, CF3, CN, or (3-4C)cycloalkyl;
• R3, R3a and R3b are independently hydrogen, (1-6C)alkyl, CF3, F, Cl, CN or (3-6C)cycloalkyl;
• R4 is hydrogen, and
• R5 is hydrogen, (3-6C)cycloalkyl (optionally substituted by one or more halogens), (3-6C)cycloalkylCH2— (optionally substituted by one or more halogens), (1-6C)alkyl, a 4-6 membered heterocycle having 1-2 ring heteroatoms independently selected from N, O and S, or phenyl optionally substituted with one or more halogens,
• or R4 and R5 together with the carbon atom to which they are attached form a 4- or 5-membered azacyclic ring substituted with a substituent selected from fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, (1-6Calkyl)C(═O)O—, —SO2Rc, (1-6C)alkyl, (1-6Calkyl)C(═O)—, phenylC(═O)—, cyclopropyl-C(═O)—, (1-6C alkyl)NHC(═O)—, di(1-6C alkyl)NC(═O)—, or cyano(1-6Calkyl),
• or R4 and R5 together with the carbon atom to which they are attached form a 3-6-membered carbocyclic ring optionally substituted with one or more substitutents independently selected from methyl and halogen;
• Rc is H, fluoro(1-3C)alkyl, difluoro(1-3C)alkyl trifluoro(1-3C)alkyl, (3-6C)cycloalkyl, cyclopropylamino, cyclopropylmethyl, (1-6C)alkyl, or a 5-membered heteroaryl having 1-2 ring heteroatoms independently selected from N, O and S, wherein said 5-membered heteroaryl is optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• and
• R6 is H, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, (3-6C cycloalkyl)(1-3C)alkyl, hydroxy(1-6C)alkyl, (1-3C alkoxy)(1-6C)alkyl, (1-3C alkylsufanyl)(1-3C)alkyl, (1-3C alkyl)OC(═O)(1-3C)alkyl, carboxy(1-6C)alkyl, fluoro(2-6C)alkenyl, difluoro(2-6C)alkenyl or (1-6C)alkylC(═O)CH2—.