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US 2014/0228338 A1Published application
Topical ocular analgesic agents
AssigneeNovartis AG
InventorsMartha E. Gadd, Peter G. Klimko, Karen C. David, Kenneth C. Appell, Mark R. Hellberg
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Abstract
The topical ophthalmic use of certain 2,4-diamino-substituted 1,3-triazines for preventing or alleviating ocular pain in patients is disclosed. Topcial ocular pharmaceutical composition are also disclosed.
Claims12
A method for the treatment of ocular pain which comprises administering to a patient in need thereof a topical ophthalmic formulation containing a therapeutically effect amount of at least one compound of Formula I
- wherein:
- Y═CH or N;
- n=0 or 1, with the proviso that n=0 if Y═N;
- X=a direct bond or CH2;
- Z=a phenyl or heteroatomic group, optionally substituted with phenyl, methyl;
- halo, trihalomethyl, or trihalomethoxy;
- and
- R2═H, Me, or F, with the Me or F groups in the 2 or 6 positions on the acetamide-bearing phenyl ring.
5 more elements
A topical ocular pharmaceutical composition comprising:
- a cyclodextrin or sodium polystyrene sulfonate;
- and
- a therapeutically effect amount of compound of Formula I
- wherein:
- n1Y═CH or N;
- n=0 or 1, with the proviso that n=0 if Y═N;
- X=a direct bond or CH2;
- Z=a phenyl or heteroatomic group, optionally substituted with phenyl, methyl;
- halo, trihalomethyl, or trihalomethoxy;
- and
- R2═H, Me, or F, with the Me or F groups in the 2 or 6 positions on the acetamide-bearing phenyl ring.
8 more elements
Dependencies are inferred from the claim text.