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US 2014/0228337 A1Published application
Tazobactam Arginine Compositions
AssigneeCubist Pharmaceuticals, Inc.
InventorsJan-Ji Lai, Jian-Qiao Gu, Pradip M. Pathare, Valdas Jurkauskas, Joseph Terracciano, Nicole Miller Damour
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Abstract
This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.
Claims22
1-6. (canceled)
A composition obtained by a process comprising the steps of:
- a) combining L-arginine, tazobactam acid and acetone in an aqueous solution at a pH of 5.9+/−0.5;
- b) allowing a solid tazobactam arginine composition to precipitate from the aqueous solution;
- and
- c) obtaining the solid tazobactam arginine composition from the aqueous solution.
1 more element
A composition obtained by a method comprising the steps of:
- a) combining L-arginine, tazobactam acid and isopropanol in an aqueous solution;
- b) allowing a solid tazobactam arginine composition to precipitate from the aqueous solution;
- and
- c) obtaining the solid tazobactam arginine composition from the aqueous solution.
1 more element
A pharmaceutical composition obtained by a process comprising the steps of:
- a) combining tazobactam, L-arginine in an aqueous solution with an antisolvent selected from the group consisting of acetone and isopropanol;
- b) allowing a solid composition comprising tazobactam and L-arginine to precipitate from the aqueous solution;
- c) obtaining the solid composition from the aqueous solution and
- d) combining the solid composition with a beta lactam antibiotic in a pharmaceutical composition comprising tazobactam and L-arginine.
1 more element
Dependencies are inferred from the claim text.