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US 2014/0228325 A1Published application
Alkene derivatives as sphingosine 1-phosphate (s1p) receptor modulators
AssigneeAllergan, Inc.
InventorsWenkui K. Fang, Ken Chow, Evelyn G. Corpuz
Life of this patent
Estimating the term…
Abstract
The present invention relates to alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Claims15
A compound represented by Formula I, or an E geometric isomer, or a Z geometric isomer, or a mixture of an E and a Z geometric isomers, or an enantiomer, or a diastereoisomer, or a tautomer, or a zwitterion, or a pharmaceutically acceptable salt thereof,
- wherein:
- A is optionally substituted C6-10 aryl, optionally substituted heterocycle, optionally substituted C3-8 cycloalkyl or optionally substituted C3-8 cycloalkenyl;
- B is optionally substituted C6-10 aryl, optionally substituted heterocycle, optionally substituted C3-8 cycloalkyl or optionally substituted C3-8 cycloalkenyl;
- R1 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, NR14R15 or hydroxyl;
- R2 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, NR14R15 or hydroxyl;
- R3 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, NR14R15 or hydroxyl;
- R4 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, NR14R15 or hydroxyl;
- R5 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, NR14R15 or hydroxyl;
- R6 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, NR14R15 or hydroxyl;
- R7 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, optionally substituted C6-10 aryl, optionally substituted heterocycle, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkenyl, NR14R15 or hydroxyl;
- R8 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, optionally substituted C6-10 aryl, optionally substituted heterocycle, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkenyl, NR14R15 or hydroxyl;
- R9 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, optionally substituted C6-10 aryl, optionally substituted heterocycle, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkenyl, NR14R15 or hydroxyl;
- R10 is H, halogen, —OC1-8 alkyl, optionally substituted C1-8 alkyl, CN, C(O)R13, optionally substituted C6-10 aryl, optionally substituted heterocycle, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkenyl, NR14R15 or hydroxyl;
- R11 is H or optionally substituted C1-8 alkyl;
- R12 is OPO3H2, carboxylic acid, PO3H2, optionally substituted C1-6 alkyl, —S(O)2H, —P(O)MeOH, —P(O)(H)OH or OR16;
- R13 is H, OH or optionally substituted C1-8 alkyl;
- R14 is H or optionally substituted C1-8 alkyl;
- R15 is H or optionally substituted C1-8 alkyl;
- R16 is H or optionally substituted C1-8 alkyl;
- L1 is O, S, S(O), NH or CH2;
- L2 is O, S or CH2,
- L3 is O, S or CH2;
- a is 1, 2, 3, 4, 5 or 6;
- b is 0 or 1;
- and
- c is 0, 1, 2, 3, 4 or 5.
23 more elements
Dependencies are inferred from the claim text.