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US 2014/0228323 A1Published application
Substituted bisphenyl butanoic phosphonic acid derivatives as nep inhibitors
AssigneeNovartis AG
InventorsDavid Weninger BARNES, Scott Louis COHEN, Dean Franklin Rigel
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Abstract
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.
Claims22
A compound of the formula (I):
- wherein:
- R1 is H;
- —C1-7alkyl or C6-10aryl;
- wherein alkyl is optionally substituted with one or more substituents independently selected from the group consisting of —O—C(O)—O—C3-7cycloalkyl, —O—C(O)—C3-7cycloalkyl, —O—C(O)—C6-10aryl, —O—C(O)—O—C6-10aryl, —O—C(O)—O—C1-7alkyl, —O—C(O)—C1-7alkyl, heteroaryl, heterocyclyl, —C(O)-heterocyclyl, —C(O)NH2, —C(O)NH—C1-7alkyl, and —C(O)N(C1-7alkyl)2;
- R2 is Cl, CH3 or F;
- R3 is H, F, Cl, CH3 or OCH3, or
- a pharmaceutically acceptable salt thereof.
4 more elements
16-19. (canceled)
Dependencies are inferred from the claim text.