Crystallization of idarubicin hydrochloride
AssigneeHeraeus Precious Metals GmbH & Co. KG
InventorTero Kunnari
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Abstract
A method is provided for production of crystalline idarubicin hydrochloride, the method including the steps of: (i) producing a mixture containing (a) idarubicin hydrochloride, (b) at least one alcohol selected from 1-butanol, 2-butanol, and 1-pentanol, and (c) water; and (ii) crystallizing idarubicin hydrochloride from this mixture. A crystalline idarubicin hydrochloride is also provided characterized by a powder x-ray diffraction pattern in which at least reflexes at diffraction angles occur in the following ranges (in 2Θ): 7.2-7.7; 11.7-12.2; 16.2-16.7; 16.7-17.2; 19.6-20.1; 19.8-20.3; 22.2-22.7, and 22.9-23.4.
Claims20
1-16. (canceled)
A method for production of crystalline idarubicin hydrochloride, the method comprising steps of:
- (i) producing a mixture containing (a) idarubicin hydrochloride, (b) a least one alcohol selected from 1-butanol, 2-butanol, and 1-pentanol, and (c) water;
- and
- (ii) crystallizing idarubicin hydrochloride from this mixture.
Crystalline idarubicin hydrochloride, characterized by a powder x-ray diffraction pattern in which at least reflexes at diffraction angles occur in the following ranges (in 2Θ):
- 7.2-7.7;
- 11.7-12.2;
- 16.2-16.7;
- 16.7-17.2;
- 19.6-20.1;
- 19.8-20.3;
- 22.2-22.7, and 22.9-23.4.
Dependencies are inferred from the claim text.