Natriuretic polypeptides with unique pharmacologic profiles
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn C. Burnett, JR., Candace Y.W. Lee
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Abstract
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
Claims28
1-37. (canceled)
A method for treating a mammal having a cardiovascular condition or renal condition, wherein said method comprises administering, to said mammal, a composition comprising a polypeptide under conditions wherein the severity of a manifestation of said cardiovascular condition or renal condition is reduced, wherein said polypeptide is less than 44 amino acid residues in length and comprises, in an order from amino terminus to carboxy terminus:
- (a) the sequence set forth in SEQ ID NO:6 or the sequence set forth in SEQ ID NO:6 with no more than two additions, subtractions, or substitutions,
- (b) the sequence set forth in SEQ ID NO:2 or the sequence set forth in SEQ ID NO:2 with no more than one addition, subtraction, or substitution, and
- (c) the sequence set forth in SEQ ID NO:7 or the sequence set forth in SEQ ID NO:7 with no more than two additions, subtractions, or substitutions.
A method for increasing natriuretic activity within a mammal, wherein said method comprises administering, to said mammal, a composition comprising a polypeptide under conditions wherein natriuretic activity within said mammal is increased and under conditions wherein the renal perfusion pressure of said mammal is maintained to a greater extent than the renal perfusion pressure maintained in a control mammal administered human BNP, wherein said polypeptide is less than 44 amino acid residues in length and comprises, in an order from amino terminus to carboxy terminus:
- (a) the sequence set forth in SEQ ID NO:6 or the sequence set forth in SEQ ID NO:6 with no more than two additions, subtractions, or substitutions,
- (b) the sequence set forth in SEQ ID NO:2 or the sequence set forth in SEQ ID NO:2 with no more than one addition, subtraction, or substitution, and
- (c) the sequence set forth in SEQ ID NO:7 or the sequence set forth in SEQ ID NO:7 with no more than two additions, subtractions, or substitutions.
Dependencies are inferred from the claim text.