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AssigneeArts Biologics A/S
InventorsPeter Nordkild, Svend Lindenberg, Claus Yding Andersen, Kim Vilbour Andersen
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The present invention relates to a long acting biologically active luteinizing hormone (LH) compound comprising an LH agonist linked to a pharmaceutically acceptable molecule providing an in vivo plasma half-life of the LH agonist or LH compound which is increased substantially compared to the in vivo plasma half-life of an LH agonist administered in the same manner as the LH compound. The present invention relates to methods for controlled ovarian stimulation which can be used in conjunction with assisted reproduction technologies such as in vitro fertilisation, intra cytoplasmatic sperm injection, intra uterine insemination and in vitro maturation. In other aspects the invention relates to methods for inducing folliculogenesis and methods for providing luteal support for the corpora lutea.
1-128. (canceled)
A long acting biologically active luteinizing hormone (LH) compound comprising a mammal CG or a mammal LH fused to an albumin, wherein the albumin is fused to an N-terminal or a C-terminal of the mammal CG or an N-terminal or a C-terminal of the mammal LH, optionally through a peptide linker
Dependencies are inferred from the claim text.