Post procedure skin care gel and methods of use thereof
AssigneeJan Marini Skin Research
InventorsSUBHASH J. SAXENA, JAN MARINI
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Abstract
Compositions and methods are provided for a post-procedure care following the treatment of skin with cosmetic skin resurfacing treatments, which include without limitation a variety of laser treatments, chemical peeling and dermabrasion, by applying a silicone-based gel formulation in combination with therapeutic peptides. Peptides of interest include one or more of transforming growth factor, epidermal growth factor, and basic fibroblast growth factor. The formulation may further comprise an effective dose of one or more acylated peptides, which peptides are active in remodeling of the skin.
Claims19
A silicone-based gel comprising:
- from 75% to 95% cyclic dimethyl polysiloxane;
- at least one of Transforming growth Factor (TGFβ1) at a concentration of from 500 pg/ml to 500 μg/ml;
- Epidermal Growth Factor (EGF) at a concentration of from 500 pg/ml to 500 μg/ml;
- and Basic Fibroblast Growth Factor (FGF) at a concentration of from 250 pg/ml to 250 μg/ml;
- acylated peptides of 3 to 10 amino acids in length comprising at least one lipid moiety at a concentration of from 0.05% to 12%;
- in a cosmetically acceptable vehicle.
A method for post-procedure treatment following a skin resurfacing procedure, comprising:
- topically applying to the skin of the subject from 1 to 100 ml. of a silicone-based gel comprising:
- from 85% to 95% cyclic dimethyl polysiloxane;
- at least one of Transforming growth Factor (TGFβ1) at a concentration of from 500 pg/ml to 500 μg/ml;
- Epidermal Growth Factor (EGF) at a concentration of from 500 pg/ml to 500 μg/ml;
- and Basic Fibroblast Growth Factor (FGF) at a concentration of from 250 pg/ml to 250 μg/ml;
- acylated peptides of 3 to 10 amino acids in length comprising at least one lipid moiety at a concentration of from 0.05% to 12%;
- in a cosmetically acceptable vehicle.
Dependencies are inferred from the claim text.