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US 2014/0228282 A1Published application
Fibroblast growth factor 21 proteins
AssigneeEli Lilly and Company
InventorsRyan James Darling, Craig Duane Dickinson, David Albert Driver, Malgorzata Donata Gonciarz
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Abstract
This present invention relates to pharmacologically potent and stable human fibroblast growth factor 21 (FGF21) proteins, pharmaceutical compositions comprising FGF21 proteins, and methods for treating type 2 diabetes, obesity, dyslipidemia, and/or metabolic syndrome using such proteins.
Claims12
1-14. (canceled)
An FGF21 protein having an amino acid sequence of:
- (SEQ ID NO 15)
- ESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQ
- EDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKE
- YKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCL
- VKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQ
- EGNVFSCSVMHEALHNHYTQKSLSLSLGGGGGSGGGGSGGGGSAHPIPDS
- SPLLQFGGQVRQRYLYTDDAQQTECHLEIREDGTVGCAADQSPESLLQLK
- ALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFREX1LX2EDGY
- NVYQSEAHGLPLHLPGDKSPHRKPAPRGPARFLPLPGLPPALPEPPGILA
- PQPPDVGSSDPLRLVEPSQLX3SPSFX4X5
- wherein X1 is L or D, X2 is L or K, X3 is R or L, X4 is L or E, and X5 is G or is absent.
8 more elements
Dependencies are inferred from the claim text.