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US 2014/0228276 A1Published application
Regulation of Sodium Channels by PLUNC Proteins
AssigneeThe University of North Carolina at Chapel Hill
InventorsRobert Tarran, Monroe Jack Stutts, Scott Donaldson
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Abstract
The present invention relates to the ability of PLUNC proteins, such as SPLUNC1 and SPLUNC2, to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of PLUNC proteins to sodium channels.
Claims21
1-47. (canceled)
A polypeptide consisting essentially of the amino acid sequence of SEQ ID NO:11 or a functional fragment or homolog thereof that binds to a sodium channel.
Dependencies are inferred from the claim text.