Compositions and methods for influencing satiety, lipid metabolism, and fat utilization
AssigneeNestec S.A.
InventorsDelphine Tissot-Favre, Frederic Destaillats, Clementine Thabuis, Jean-Charles Martin
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Abstract
The invention provides (1) genes differentially expressed in animals administered fatty acid amides that affect one or more of food intake, satiety, lipid metabolism, and fat utilization and (2) compositions and methods relating to the use of the genes to identify new compounds that affect one or more of food intake, satiety, lipid metabolism, and fat utilization.
Claims18
A combination comprising two or more chemically synthesized or chemically modified polynucleotides that specifically hybridize to two or more target polynucleotides that are differentially expressed in animals exhibiting a phenotype comprising a decrease in body fat and plasma triglycerides and an increase in satiety as measured by decreased food intake (RBF/IS phenotype) resulting from extended regular ingestion of a substance that affects one or more of food intake, satiety, lipid metabolism, and fat utilization, the target polynucleotide comprising a gene selected from genes encoding proteins FAT/CD36, FAAH, adiponectin, or ACO.
A composition comprising two or more probes for detecting differential gene expression in animals exhibiting a phenotype comprising a decrease in body fat and plasma triglycerides and an increase in satiety as measured by decreased food intake (RBF/IS phenotype) resulting from extended regular ingestion of a substance that affects one or more of food intake, satiety, lipid metabolism, and fat utilization, wherein the probes comprise:
- a) chemically modified polynucleotides that specifically hybridize to two or more genes encoding proteins FAT/CD36, FAAH, adiponectin, or ACO;
- or
- b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins FAT/CD36, FAAH, adiponectin, or ACO.
A device comprising a solid support to which is affixed an array comprising a plurality of probes for detecting differential gene expression in animals exhibiting a phenotype comprising a decrease in body fat and plasma triglycerides and an increase in satiety as measured by decreased food intake (RBF/IS phenotype) resulting from extended regular ingestion of a substance that affects one or more of food intake, satiety, lipid metabolism, and fat utilization, wherein the probes comprise:
- a) polynucleotides that specifically hybridize to two or more genes encoding proteins FAT/CD36, FAAH, adiponectin, or ACO;
- or
- b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins FAT/CD36, FAAH, adiponectin, or ACO.
Dependencies are inferred from the claim text.