Detection and Assay Devices and Methods of Making and Using the Same
AssigneeSentilus, Inc.
InventorsAshutosh CHILKOTI, Angus HUCKNALL
Life of this patent
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Abstract
An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.
Claims53
-35. (canceled)
A method of non-covalently binding a first member of a specific binding pair to a non-fouling polymer layer, comprising depositing the first member of the specific binding pair on the non-fouling polymer layer which retains water of hydration, wherein the first member of a specific binding pair is non-covalently bound to the non-fouling polymer layer.
A non-fouling polymer layer comprising a first member of a specific binding pair which is non-covalently bound to the non-fouling polymer layer.
Dependencies are inferred from the claim text.