Prognostic methods and compositions for predicting interferon treatment eficacy in a subject
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorYoav Smith
Life of this patent
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Abstract
The present invention relates to methods, compositions and kits for predicting, assessing and evaluating responsiveness and success of interferon treatment as well as methods for monitoring disease progression and pathophysiology in a subject treated with interferon, using miR-146a and optionally at least one of miR-146a regulated genes as biomarkers.
Claims25
A prognostic method for predicting, assessing and monitoring responsiveness of a mammalian subject to interferon treatment, said method comprising the steps of:
- (a) determining the level of expression of miR-146a and optionally of at least one of miR-146a regulated genes in a biological sample of said subject to obtain an expression value;
- (b) comparing the expression value obtained in step (a) to a predetermined standard expression value or to an expression value of miR146a and optionally of at least one of miR-146a regulated genes in at least one control sample;
- thereby predicting, assessing and monitoring responsiveness of a mammalian subject to interferon treatment
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A prognostic composition comprising:
- (a) detecting molecules specific for determining the level of expression of miR-146a in a biological sample;
- and
- (b) detecting molecules specific for determining the level of expression of at least one of miR-146a regulated genes in a biological sample;
- optionally, said detecting molecules of (a) and (b) are attached to a solid support,
- wherein said composition is for predicting, assessing and monitoring responsiveness of a mammalian subject to interferon treatment.
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A kit comprising:
- (a) detecting molecules specific for determining the level of expression of miR-146a in a biological sample;
- (b) detecting molecules specific for determining the level of expression of at least one of miR-146a regulated genes in a biological sample;
- and optionally at least one of:
- (c) pre-determined calibration curve providing standard expression values of at least one of miR-146a and of at least one of miR-146a regulated genes;
- (d) at least one control sample.
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Dependencies are inferred from the claim text.