Genes and polypeptides relating to breast cancers
AssigneeOncotherapy Science, Inc.
InventorsYusuke NAKAMURA, Toyomasa KATAGIRI, Shuichi NAKATSURU
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Abstract
The present application provides novel human genes A7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes F3374 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer. The invention features methods of screening for modulators of the kinase activity of PBK/TOPK. The invention further provides methods of screening for agents to prevent or treat cancer, such as breast cancer.
Claims3
1-6. (canceled)
A method of screening for a compound for treating or preventing breast cancer, said method comprising the steps of:
- (a) contacting an A7322 with a PHB2/REA or functional equivalent thereof in the presence of a test compound, wherein the A7322 is a polypeptide selected from the group consisting of:
- (1) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 80 (A7322);
- (2) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 80 wherein one or more amino acids are substituted, deleted, or inserted, provided said polypeptide has a biological activity equivalent to the polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 80;
- (3) a polypeptide encoded by a polynucleotide that hybridizes under stringent conditions to a polynucleotide consisting of the nucleotide sequence of SEQ ID NO:
- 79, provided the polypeptide has a biological activity equivalent to a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 80;
- (b) detecting the binding between the polypeptides of step (a);
- and
- (c) selecting the test compound that inhibits the binding between the A7322 and PHB2/REA polypeptides.
(canceled)
Dependencies are inferred from the claim text.