In vitro method for predicting semen fertility
AssigneesFundacio Puigvert, Instiut D' Investigació BiomèDica De Bellvitge (Idbell)
InventorsSara Larriba Bartolomé, Lluís Bassas Arnau
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Abstract
In vitro method for predicting fecundity of semen. The present invention belongs to the field of reproductive medicine, particularly related to male and female infertility. Thus, the present invention is focused on the evaluation and assessment of the sperm expression gene profile, in order to identify a specific group of genes whose expression profile is correlated with the fecundity ability of spermatozoa. This group of genes could be used as biomarkers for discriminating those samples with the worst ability to fertilize oocyte.
Claims8
An in vitro method for predicting fecundity ability of spermatozoa, said method comprising analyzing the expression profile of at least one of the following genes:
- EIF5A, RPL13, RPL23A, RPS27A, RPS3, RPS8 or TOMM7, or combinations thereof,
- wherein the genes EIF5A, RPL13, RPL23A, RPS27A, RPS3, RPS8 or TOMM7 are infra-expressed in samples with low fecundity ability as compared with their corresponding expression level thresholds in samples with optimal fecundity ability.
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