Stress tolerant bifidobacteria
AssigneeNestec S.A.
InventorsBernard Berger, Ernea Rezzonico, Fabrizio Arigoni
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Abstract
The present invention relates in general to the field of Bifidobacteria. In particular, the present invention relates to the field of Bifidobacteria with a modulated stress resistance. One embodiment of the present invention is a Bifidobacterium with a constitutively modulated DnaK, GrpE and/or CIpB expression.
Claims4
A method to increase the stress resistance of a Bifidobacterium comprising the step of constitutively upregulating an expression of a gene selected from the group consisting of DnaK, DnaJ, GrpE, C1pB and combinations thereof, by introducing at least one point mutation in the hspR gene of the Bifidobacterium so that a characteristic selected from the group consisting of HspR expression, HspR functioning and a combination thereof is hindered.
Dependencies are inferred from the claim text.