MicroRNA and Methods for Inhibiting Same
AssigneeThe Rockefeller University
InventorsMarkus Stoffel, Matthew N. Poy, Thomas H. Tuschl
Life of this patent
Estimating the term…
Abstract
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to isolated single stranded pancreatic islet microRNA molecules or anti-pancreatic islet microRNA molecules.
Claims39
An isolated nucleic acid molecule comprising a maximum of fifty moieties, wherein each moiety comprises a base bonded to a backbone unit, said molecule comprising the sequence of bases identified in SEQ. ID. NO. 10, wherein the molecule comprises at least one modified moiety for increased nuclease resistance.
An isolated nucleic acid molecule consisting of the sequence of bases of SEQ ID NO:
- 10, wherein the molecule comprises at least one modified moiety for increased nuclease resistance.
An isolated nucleic acid molecule comprising a maximum of 500 moieties, wherein each moiety comprises a base bonded to a backbone unit, said molecule comprising the sequence of bases identified in the hairpin precursor of SEQ ID NO. 30, wherein the molecule comprises at least one modified moiety for increased nuclease resistance.
An isolated nucleic acid molecule consisting of the sequence of bases identified in the hairpin precursor of SEQ ID NO. 30, wherein the molecule comprises at least one modified moiety for increased nuclease resistance.
Dependencies are inferred from the claim text.