# US 2014/0227770 A1 · Uses of reagents in sample collection and cartridge systems

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- Number: US 2014/0227770 A1
- Document ID: US20140227770A1
- Status: Published application
- Kind: A1
- Application number: 14/170,964
- Filed: 2014-02-03
- Published: 2014-08-14
- Earliest claimed: 2008-03-20
- Assignees: Scitech Corporation
- Applicants: Scitech Corporation
- Inventors: Prabhjyot Dehal; David Pritchard; Claire Geekie
- Web page: https://patentgrep.com/patent/US20140227770A1

## CPC

- B01L 3/523: {with means for closing or opening}
- B01L 3/502715: {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
- B01L 3/5082: {Test tubes per se}
- G01N 33/54326: {Magnetic particles}
- B01L 2200/10: Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
- B01L 2200/16: Reagents, handling or storing thereof
- B01L 2300/06: Auxiliary integrated devices, integrated components
- B01L 2300/0832: cylindrical, tube shaped
- Y10T 436/10: Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T 436/107497: Preparation composition [e.g., lysing or precipitation, etc.]
- Y10T 436/25: including sample preparation
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A sample collection container and a cartridge system employ reagent bodies having reagents confined by a restraining agent. The sample collection container comprises one or more reagent bodies, each having one or more reagents confined by a restraining agent. The restraining agent is capable of being broken down to release the reagents which are dispersed through the restraining agent. The cartridge system comprises a reagent component for storing reagents and a processing component for processing the reagents in an assay. At least one of the components includes one or more reagent bodies, each having one or more reagents confined by a restraining agent capable of being broken down. The reagent component and the processing component are configured to be coupled together to form a cartridge, the reagent component and/or the processing component having at least one compartment to accept waste from the assay.

## Claims

### Claim at position 1

-40. (canceled)

### Claim 41

A cartridge system comprising:
(a) a reagent component for storing one or more reagents; and
(b) a processing component for processing the one or more reagents in an assay;
wherein one or more of the components comprise one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent;
and further wherein the reagent component and the processing component are configured to be coupled together to form a cartridge, and wherein the reagent component and/or the processing component comprise at least one compartment configured to accept waste from the assay, the reagent component not taking part in processing the reagents in the assay, except to accept waste from the processing component.

### Claim 42 (depends on 41)

A cartridge system according to claim 41, further comprising a sensing component comprising at least one sensing element for detecting an analyle.

### Claim 43

A cartridge system comprising:
(a) a reagent component for storing one or more reagents;
(b) a processing component for processing one or more reagents in an assay; and
(c) a sensing component comprising at least one sensing element for detecting an analyte;
wherein one or more of the components comprise one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent;
and further wherein the reagent component, the processing component and the sensing component are separate components configured to be coupled together to form a cartridge.

### Claim 44

A cartridge system comprising:
(a) a reagent component for storing one or more reagents;
(b) a processing component for processing one or more reagents in an assay; and
(c) a sample preparation component for preparing a sample for the assay;
wherein one or more of the components comprise one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent;
and further wherein the reagent component and the processing component are configured to be coupled together to form a cartridge.

### Claim 45 (depends on 44)

A cartridge system according to claim 44, wherein the sample preparation component comprises the one or more of the reagent bodies.

### Claim 46 (depends on 41)

A cartridge system according to claim 41, wherein the processing component comprises one or more of the reagent bodies.

### Claim 47 (depends on 41)

A cartridge system according to claim 41, wherein the reagent component comprises one or more of the reagent bodies.

### Claim 48 (depends on 47)

A cartridge system according to claim 47, which system is configured such that coupling the reagent component to the processing component causes a fluid to pass into the reagent component, wherein the fluid dissolves the restraining agent of the one or more reagent bodies to release the one or more reagents into the processing component from the reagent component.

### Claim 49 (depends on 48)

A cartridge system according to claim 48, wherein a sample acts to dissolve the restraining agent of the one or more reagent bodies to release the one or more reagents from the reagent bodies.

### Claim 50 (depends on 41)

A cartridge system according to claim 41, wherein either the reagent component and/or the processing component and/or the sample preparation component comprises a sample zone, configured to accept a sample.

### Claim 51 (depends on 50)

A cartridge system according to claim 50, wherein the sample zone is configured to deliver the sample to the processing component.

### Claim 52 (depends on 50)

A cartridge system according to claim 50, wherein the sample zone is configured to accept a sample collection container.

### Claim 53 (depends on 41)

A cartridge system according to claim 41, wherein the processing component comprises one or more microfluidic processing elements.

### Claim 54 (depends on 41)

A cartridge system according to claim 41, wherein the reagent component comprises a plurality of reagent storage zones.

### Claim 55 (depends on 54)

A cartridge system according to claim 54, wherein one or more of the reagent storage zones comprise one or more reagent bodies, wherein the one or more reagents are suitable for carrying out one or more processing steps selected from analyte and/or sample preparation, analyte and/or sample separation, analyte and/or sample concentration, analyte and/or sample amplification, an analyte and/or sample purification, an analyte and/or sample labelling, and an analyte and/or sample detection.

### Claim at position 17

-70. (canceled)