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US 2014/0227690 A1Published application
Methods and compositions for assessment of fetal lung maturity
AssigneeSt. John Heallth
InventorsRobert Alan Welch, Michael Kenneth Shaw
Life of this patent
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Abstract
The technology described herein relates to determination of fetal lung maturity, e.g. by non-invasive methods and methods of treatment and assays relating thereto.
Claims17
A method for antenatally assessing fetal lung maturity, including the steps of:
- collecting a sample of maternal serum;
- obtaining cell free messenger RNA (mRNA) from the sample of maternal serum;
- determining a level of cell free lysophospholipid acyltransferase 1 (LPCAT1) mRNA in the sample of maternal serum;
- comparing the level of cell free LPCAT1 mRNA in the sample of maternal serum to a reference standard relating a level of cell free LPCAT1 mRNA to a level of fetal lung maturity;
- determining the level of lung maturity of a fetus corresponding to the level of cell free LPCAT1 mRNA in the sample;
- and assessing the level of lung maturity of a fetus.
3 more elements
A method for assessing the risk of a fetus for developing neonatal respiratory distress syndrome, including the steps of:
- collecting a sample of maternal serum;
- obtaining cell free messenger RNA (mRNA) from the sample of maternal serum;
- determining a level of cell free lysophospholipid acyltransferase 1 (LPCAT1) mRNA in the sample of maternal serum;
- comparing the level of cell free LPCAT1 mRNA in the sample of maternal serum to a threshold level of cell free LPCAT1 mRNA, wherein a level of cell free LPCAT1 mRNA below the threshold level indicates risk that a fetus will develop neonatal respiratory distress syndrome;
- and
- determining whether risk a fetus is at risk of neonatal respiratory distress syndrome.
3 more elements
Dependencies are inferred from the claim text.