US 2014/0227409 A1 · COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF METABOLIC DISEASES

Abstract

The present invention is a new method and composition that enhance bone repair, formation, maintenance and slowing of bone resorption. The present invention relates to methods and compositions that enhance collagen formation, tendon health and tendon injury healing, bone maintenance and bone injury healing, and the prevention and treatment of metabolic diseases. The present invention is a part of the therapy to maintain bone health among patients with diabetic bone resorption and others with metabolic disorders. In one embodiment, the composition is a composite of hydroxyapatite and an organic matrix composed of milk pH-dependent serum proteins, i.e., bone morphogenic proteins (BMP), milk serum-derived specific proteins (MSSP), and milk serum derived proteins.

Claims9

Dependent claims

A method of making a nutritional composite material comprising the steps of

a) providing whey-derived milk minerals in solid form;
b) providing milk-derived basic protein in solution;
c) exposing the milk-derived protein solution of step b. to an ion exchange step to enhance the weight percent milk-derived basic proteins in the solution;
d) removing sodium-based minerals and sodium salts from the milk-derived basic protein solution;
e) purifying the milk-derived solid minerals by mixing the minerals with a solvent and heating the solution;
f) combining the purified milk-derived solid mineral solution of the previous step with the enhanced milk-derived basic protein solution of step d);
g) removing the solvent of the previous step to produce the nutritional composite material.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/050,810Filed 10 Oct 2013

Priority

24 Sep 2009

Published

14 Aug 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification28 codes

A61K 35/20
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A23C 9/1425
By dialysis, reverse osmosis or ultrafiltration: by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate
A23C 9/1427
By dialysis, reverse osmosis or ultrafiltration: by dialysis, reverse osmosis or hyperfiltration, e.g. for concentrating or desalting
A23C 9/146
In which the chemical composition of the milk is modified by non-chemical treatment: by ion-exchange

Family

Application61/245,505Us provisional application · filed 24 Sep 2009

Application12/890,090Continuation · filed 24 Sep 2010

Application13/567,727Continuation · filed 6 Aug 2012

Application14/050,810Continuation

US 2011/0189337 A1Published application

US 2013/0029017 A1Published application

US 8,518,453 B2Related patent

US 8,557,296 B2Related patent

US 2014/0227409 A1This patent

From the US filing history. Foreign family members aren’t listed.

Compositions and methods for the prevention and treatment of metabolic diseases

Life of this patent

Compositions and methods for the prevention and treatment of metabolic diseases

Life of this patent

Abstract

Claims9