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US 2014/0227365 A1Published application
pH BUFFERED BIOACTIVE GLASS, AND ITS PREPARATION PROCESS AND USE
AssigneeChangzhou Bio-Sheng Technology Co., LTD
InventorsJipin Zhong, Yongxiang Wang, Jiang Chang, Yuhong Xu
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Abstract
The present invention relates to a pH buffered bioactive glass, and its preparation process and use. The pH buffered bioactive glass comprises SiO2, CaO, Na2O, and P2O5, and further comprises solid acidic particles or a Tris buffer solution. The pH buffered bioactive glass can regulate the pH of formulations comprising bioactive glass, and has a good therapeutic effect with a low dosage.
Claims21
1-9. (canceled)
10:
- A pH buffered bioactive glass, characterized in that said pH buffered bioactive glass is a composition A comprising a bioactive glass and solid acidic particles, or a composition B comprising a bioactive glass and a Tris buffer solution, wherein said bioactive glass comprises SiO2, CaO, Na2O and P2O5 as the raw materials, the content of each raw material in said composition A is measured by “part by mass”, and the content of each raw material in said composition B is measured by “gram per 100 ml of Tris”,
- Composition A:
- SiO2-40 to 60;
- CaO-15 to 30;
- Na2O-15 to 30;
- P2O5-2 to 8;
- Solid acidic particles-3 to 7;
- Composition B:
- SiO2-0.0003 to 22.5 g;
- CaO-0.0001 to 12.25 g;
- Na2O-0.0001 to 12.25 g;
- P2O5-0.00004 to 3 g based on 100 ml of the Tris buffer solution,
- wherein the pH thereof is finally adjusted to 8.0±0.3.
10 more elements
11:
- The pH buffered bioactive glass according to claim 10, characterized in that said pH buffered bioactive glass is a tablet, a capsule or a suspension.
12:
- The pH buffered bioactive glass according to claim 10, characterized in that said solid acidic particles are solid citric acid particles.
13:
- The pH buffered bioactive glass according to claim 11, characterized in that said solid acidic particles are solid citric acid particles.
14:
- The pH buffered bioactive glass according to claim 12, characterized in that said composition B is a suspension.
15:
- The pH buffered bioactive glass according to claim 12, characterized in that said composition A is a tablet or a capsule.
16:
- A method for preparing the pH buffered bioactive glass according to claim 10, comprising:
- 1) a step of melting said raw materials in said ratios at high temperature to form a bioactive glass;
- and
- 2) a step of evenly mixing the above-obtained bioactive glass with the solid acidic particles (composition A) in said ratio, or the Tris buffer solution (composition B) in said ratio to obtain said pH buffered bioactive glass.
1 more element
17:
- A method for preparing the pH buffered bioactive glass according to claim 11, comprising:
- 1) a step of melting said raw materials in said ratios at high temperature to form a bioactive glass;
- and
- 2) a step of evenly mixing the above-obtained bioactive glass with the solid acidic particles (composition A) in said ratio, or the Tris buffer solution (composition B) in said ratio to obtain said pH buffered bioactive glass.
1 more element
18:
- A method for preparing the pH buffered bioactive glass according to claim 12, comprising:
- 1) a step of melting said raw materials in said ratios at high temperature to form a bioactive glass;
- and
- 2) a step of evenly mixing the above-obtained bioactive glass with the solid acidic particles (composition A) in said ratio, or the Tris buffer solution (composition B) in said ratio to obtain said pH buffered bioactive glass.
1 more element
19:
- A method for preparing the pH buffered bioactive glass according to claim 13, comprising:
- 1) a step of melting said raw materials in said ratios at high temperature to form a bioactive glass;
- and
- 2) a step of evenly mixing the above-obtained bioactive glass with the solid acidic particles (composition A) in said ratio, or the Tris buffer solution (composition B) in said ratio to obtain said pH buffered bioactive glass.
1 more element
20:
- A method for preparing the pH buffered bioactive glass according to claim 14, comprising:
- 1) a step of melting said raw materials in said ratios at high temperature to form a bioactive glass;
- and
- 2) a step of evenly mixing the above-obtained bioactive glass with the solid acidic particles (composition A) in said ratio, or the Tris buffer solution (composition B) in said ratio to obtain said pH buffered bioactive glass.
1 more element
21:
- A method for preparing the pH buffered bioactive glass according to claim 15, comprising:
- 1) a step of melting said raw materials in said ratios at high temperature to form a bioactive glass;
- and
- 2) a step of evenly mixing the above-obtained bioactive glass with the solid acidic particles (composition A) in said ratio, or the Tris buffer solution (composition B) in said ratio to obtain said pH buffered bioactive glass.
1 more element
22:
- Use of the pH buffered bioactive glass according to claim 10 in the preparation of a medicine for preventing and treating gastric and duodenum ulcers and/or in the preparation of a medicine for preventing recurrence of gastric and duodenum ulcers.
23:
- Use of the pH buffered bioactive glass according to claim 11 in the preparation of a medicine for preventing and treating gastric and duodenum ulcers and/or in the preparation of a medicine for preventing recurrence of gastric and duodenum ulcers.
24:
- Use of the pH buffered bioactive glass according to claim 12 in the preparation of a medicine for preventing and treating gastric and duodenum ulcers and/or in the preparation of a medicine for preventing recurrence of gastric and duodenum ulcers.
25:
- Use of the pH buffered bioactive glass according to claim 13 in the preparation of a medicine for preventing and treating gastric and duodenum ulcers and/or in the preparation of a medicine for preventing recurrence of gastric and duodenum ulcers.
26:
- Use of the pH buffered bioactive glass according to claim 14 in the preparation of a medicine for preventing and treating gastric and duodenum ulcers and/or in the preparation of a medicine for preventing recurrence of gastric and duodenum ulcers.
27:
- Use of the pH buffered bioactive glass according to claim 15 in the preparation of a medicine for preventing and treating gastric and duodenum ulcers and/or in the preparation of a medicine for preventing recurrence of gastric and duodenum ulcers.
28:
- The use according to claim 22, wherein said gastric and duodenum ulcers are gastric ulcers.
29:
- The use according to claim 28, wherein said gastric and duodenum ulcers are stress-induced gastric ulcers or chronic gastric ulcers.