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US 2014/0227359 A1Published application
Diketopiperazine salts for drug delivery and related methods
AssigneeMannKind Corporation
InventorsAndrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
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Abstract
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
Claims21
A microparticulate system for drug delivery comprising a composition comprising:
- microparticles of a pharmaceutically acceptable anion of a diketopiperazine compound comprising a carboxylate group, a divalent cation, and a biologically active agent.
Dependencies are inferred from the claim text.