Pharmaceutical compositions comprising entacapone, levodopa, and carbidopa

A wet granulated single oral dose pharmaceutical composition consisting of entacapone, levodopa and carbidopa, or pharmaceutically acceptable salts or hydrates thereof, microcrystalline cellulose and pharmaceutically acceptable excipients, wherein a substantial portion of entacapone or a pharmaceutically acceptable salt or hydrate thereof along with one or more pharmaceutically acceptable excipients(s) is separated from a mixture of levodopa and carbidopa or pharmaceutically acceptable salts or hydrates thereof along with microcrystalline cellulose and one or more pharmaceutically acceptable excipients(s).

A wet granulated single oral dose capsule pharmaceutical composition consisting of granules of entacapone or a pharmaceutically acceptable salts or hydrates thereof, microcrystalline cellulose and pharmaceutically acceptable excipients and granules consisting of a mixture of levodopa and carbidopa or pharmaceutically acceptable salts or hydrates thereof in combination with other pharmaceutically acceptable excipients, wherein a substantial portion of the granules of entacapone or a pharmaceutically acceptable salt or hydrate thereof, separated from the granules comprising a mixture of levodopa and carbidopa or pharmaceutically acceptable salts or hydrates thereof, microcrystalline cellulose and pharmaceutically acceptable excipients.

A wet granulated monolayer single oral dose pharmaceutical composition comprising entacapone, levodopa and carbidopa, or pharmaceutically acceptable salts or hydrates thereof and microcrystalline cellulose, wherein a substantial portion of entacapone or a pharmaceutically acceptable salt or hydrate thereof are separated from a mixture of levodopa and carbidopa or pharmaceutically acceptable salts or hydrates thereof and microcrystalline cellulose, wherein pharmaceutical composition is prepared by wet granulation.