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US 2014/0227346 A1Published application
Immunogenic combination compositions and uses thereof
AssigneeGlaxosmithkline Biologicals SA
InventorsAndrew Geall, Ethan Settembre
Life of this patent
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Abstract
This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
Claims24
An immunogenic composition comprising:
- (i) a first polypeptide antigen, and (ii) a self-replicating RNA molecule that encodes a second polypeptide antigen;
- wherein said first and second antigens are antigens from different pathogens.
An immunogenic composition comprising:
- (i) a Parvovirus polypeptide antigen, and (ii) a self-replicating RNA molecule that encodes a CMV polypeptide antigen.
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Dependencies are inferred from the claim text.