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US 2014/0227340 A1Published application
Fibers Comprising Poorly Soluble Drugs and/or Proteins
AssigneeArsenal Medical, Inc.
InventorsToby Freyman, Quynh Pham, Robert F. Mulligan, Abby N. Picard, Xuri Yan
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Abstract
The present invention relates generally to the field of electrospun fibers. In particular, the present invention relates to core-sheath fibers and related electrospinning methods. The fibers of the invention comprise poorly water soluble drugs and/or proteins.
Claims16
A structure, comprising:
- a core-sheath fiber comprising
- a core comprising a metastable first drug in a substantially amorphous state, said drug being poorly soluble in water;
- and
- a sheath comprising a first polymer, said sheath surrounding said core.
1 more element
An ingestible structure, comprising:
- a core-sheath fiber comprising
- a core comprising a first polymer and a metastable first drug in a substantially amorphous state, said drug being poorly soluble in water;
- and
- a sheath comprising a second polymer, said sheath surrounding said core;
- wherein the weight percent of said drug is at least 80% relative to said first polymer, the crystallinity of said drug is 5% or less, and a cross-sectional diameter of said fiber is up to 20 microns.
2 more elements
A method of forming a core-sheath fiber, the method comprising the steps of:
- providing a core solution comprising at least a partial suspension of protein in a non-denaturing carrier;
- providing a sheath solution comprising a polymer;
- and
- simultaneously electrospinning said core solution and said sheath solution to produce an amorphous core-sheath fiber, said core-sheath fiber comprising a core at least partially surrounded by a sheath.
1 more element
Dependencies are inferred from the claim text.