Tissue Engineering Methods and Compositions
AssigneeCytex Therapeutics, Inc.
InventorsFarshid Guilak, Bradley T. Estes, Franklin Thomas Moutos
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Abstract
Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
Claims20
A composition for use in the treatment of a tissue pathology in a subject, the composition comprising:
- (a) an adipose-derived stem (ADS) cell and an effective amount of a biologically active agent, in which the biologically activate agent is a BMP-6 polypeptide or a functional fragment thereof;
- and
- (b) a pharmaceutically acceptable carrier or excipient,
- wherein the treatment comprises exposing the ADS cell to an effective amount of said biologically active agent sufficient to induce the ADS cell to differentiate into a cell capable of treating the tissue pathology in the subject upon administration of the composition to the subject.
A joint resurfacing implant adapted for use with a predetermined joint of a subject, the implant comprising a biocompatible scaffold formed of a biocompatible textile, wherein the scaffold is configured to resurface at least a portion of an articulating surface of the predetermined joint upon implantation.
The joint resurfacing implant of claim 7, wherein the three dimensional fiber scaffold defines a plurality of interstices throughout said scaffold, the interstices having a pore size ranging from about 1 μm to about 1,000 μm.
A joint resurfacing implant adapted for use with a predetermined joint of a subject, the implant comprising:
- (a) a scaffold comprising a biocompatible textile material;
- and
- (b) one or more cells, wherein the scaffold and one or more cells are adapted to resurface at least a portion of an articulating surface of the predetermined joint upon implantation.
Dependencies are inferred from the claim text.