Method of delivering nasal spray
AssigneeNovartis AG
InventorsGerald D. Cagle, G. Michael Wall
Life of this patent
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Abstract
A method of delivering a nasal spray. A sprayer having a formulation comprising olopatadine is provided. A spray of the formulation is delivered to a subject's nose. The spray may have a spray characteristic comprising a spray pattern having a longest axis of 20-45 mm, a shortest axis of 14-20 mm, and an ellipticity of 1-1.8. The spray may also have a spray characteristic comprising a droplet size distribution having a D10 of 15-30 μm, a D50 of 30-60 μm, a D90 of 50-150 μm, a SPAN of not more than 3, and a % Volume of <10 μm of less than 4%.
Claims19
A method of delivering a nasal spray comprising the steps of:
- providing a sprayer having a formulation comprising olopatadine;
- and
- delivering a spray of said formulation to a subject's nose having a spray characteristic comprising a spray pattern having a longest axis of 20-45 mm, a shortest axis of 14-20 mm, and an ellipticity of 1-1.8.
A method of delivering a nasal spray comprising the steps of:
- providing a sprayer having a formulation comprising olopatadine;
- and
- delivering a spray of said formulation to a subject's nose having a spray characteristic comprising a droplet size distribution having a D10 of 15-30 μm, a D50 of 30-60 μm, a D90 of 50-150 μm, a SPAN of not more than 3, and a % Volume of <10 lam of less than 4%.
A method of delivering a nasal spray comprising the steps of:
- providing a sprayer having a formulation comprising olopatadine;
- and
- delivering a spray of said formulation to a subject's nose having a spray characteristic comprising:
- a spray pattern having a longest axis of 20-45 mm, a shortest axis of 14-20 mm, and an ellipticity of 1-1.8;
- and
- a droplet size distribution having a D10 of 15-30 μm, a D50 of 30-60 μm, a D90 of 50-150 μm, a SPAN of not more than 3, and a % Volume of <10 μm of less than 4%.
Dependencies are inferred from the claim text.