Anti-viral compounds
AssigneeKineta, Inc.
InventorsShawn P. Iadonato, Kristin Bedard, Myra Wang Imanaka, Kerry W. Fowler
Life of this patent
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Abstract
Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
Claims26
A compound represented by the formula
- wherein a dashed line represents the presence or absence of a bond;
- W is selected from a bond, O, S, NR1 or CRaRb;
- X1 is CR5 or N;
- X2 is CR6 or N;
- Ra, Rb, R1, R2, R3, R4, R5, and R6 are each independently H, optionally substituted hydrocarbyl, optionally substituted aryl, or optionally substituted heteroaryl;
- Y1 and Y2 are independently C or N;
- and,
- Z1 and Z2 are independently CRaRb, C═O, CORa, CNRaRb or C═NRa.
A compound of any one of the preceding claims, wherein R2 is CH3.
A compound of any one of the preceding claims, wherein R3 is optionally substituted fur-2-yl.
A compound of any one of the preceding claims, wherein R4 is optionally substituted benzyl.
A compound of any one of the preceding claims, wherein X1 is N.
A compound of any one of the preceding claims, wherein X2 is N.
A compound of any one of the preceding claims, wherein Y1 is N.
A compound of any one of the preceding claims, wherein Y2 is N.
A compound of any one of the preceding claims, wherein Z1 is C═O.
A compound of any one of the preceding claims, wherein Z2 is C═O.
Dependencies are inferred from the claim text.