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US 2014/0227320 A1Published application
Anti-viral compounds
AssigneeKineta, Inc.
InventorsShawn P. Iadonato, Kristin Bedard, Myra Wang Imanaka, Kerry W. Fowler
Life of this patent
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Abstract
Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
Claims27
A compound represented by the formula
- wherein a dashed line indicates the presence or absence of a bond;
- R1 is Ra, OR2 or NR2R3;
- each Ra is independently H, optionally substituted hydrocarbyl, optionally substituted aryl, optionally substituted heteroaryl;
- R2 and R3 are each independently Ra, CORa, or SO2Ra;
- Y1, Y2, Y3 and Y4 are each independently CR4 or N;
- each R4 is independently R2, ORa, NR2R3, SRa, SORa, SO2Ra, SO2NHRa, NCORa, halogen, trihalomethyl, CN, S═O, or nitro;
- R5 is Ra, CORa, SO2Ra, or is not present;
- V is CR2, CR2R3, C═O, COCR2R3, or C═NR2;
- and,
- W and X are each independently N, NRa, O, S, CR2R4 or CR4.
7 more elements
A compound having a formula:
Dependencies are inferred from the claim text.