Beta-lactam compounds for enhancing t cell-mediated immune responses
AssigneeStem Cell Medicine Ltd.
InventorsIrun R. Cohen, Felix Mor
Life of this patent
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Abstract
Compositions and methods are provided, comprising at least one beta-lactam compound selected from the group consisting of cefuroxime, a penicillin, ceftriaxone, clavulanic acid, 6-aminopenicillanic acid (6-APA) and tazobactam, for enhancing T cell mediated immune responses in a subject, such as anti-tumor and anti-viral immune responses.
Claims25
1-40. (canceled)
A method for enhancing a T cell mediated immune response in a subject, the method comprising administering to the subject a pharmaceutical composition comprising a beta-lactam compound or a salt thereof selected from the group consisting of cefuroxime, a penicillin, ceftriaxone, clavulanic acid, 6-aminopenicillanic acid (6-APA) and tazobactam.
A method for enhancing a T-cell-mediated immune response in a subject, the method comprising:
- (i) incubating T cells collected from the subject with a beta-lactam compound capable of enhancing T cell activity, wherein the beta-lactam compound is selected from the group consisting of cefuroxime, a penicillin, ceftriaxone, clavulanic acid, 6-APA and tazobactam;
- and (ii) re-infusing said T cells to said subject.
A method for ex-vivo enhancement of anti-tumor activity of T cells, the method comprising incubating the T cells with a beta-lactam compound selected from the group consisting of cefuroxime, a penicillin, ceftriaxone, clavulanic acid, 6-APA and tazobactam.
Dependencies are inferred from the claim text.