A1 moiety of cholera toxin a subunit as an adjuvant for mucosal and systemic vaccines
AssigneeInternational Vaccine Institute
InventorsCecil Czerkinsky, Manki Song
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Abstract
The present invention relates to cholera toxin CTA1 protein fragments, adjuvant compositions, and methods relating to adjuvants for vaccines. The invention also relates to using recombinant CTA1 fragments conjugated to a polypeptide containing a protein transduction domain or cell-penetrating peptide as an immunomodulator.
Claims26
A fusion protein comprising an A1 subunit of a bacterial enterotoxin selected from the group consisting of cholera toxin A1 and Escherichia coli heat-labile enterotoxin A1, conjugated at the amino terminus, carboxy terminus, or both amino and carboxy terminus with a polypeptide belonging to the class of protein transduction domains or cell-penetrating peptides.
An isolated polypeptide comprising an amino acid sequence of SEQ ID NO:5.
Dependencies are inferred from the claim text.