Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
AssigneeBiondVax Pharmaceuticals Ltd.
InventorsTamar Ben-Yedidia, George H. Lowell
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Abstract
The present invention relates to use of multimeric multi-epitope peptide-based compositions for immunizing subjects against influenza by administering the compositions to the subject prior to or together with seasonal or pandemic influenza vaccines. The present invention also relates to compositions that include a multimeric multi-epitope polypeptide and a seasonal or pandemic preparation against influenza.
Claims21
1-33. (canceled)
A method for improving a protective effect or enhancing the efficacy of seasonal or pandemic influenza vaccine comprising vaccination of a subject, prior to, or together with, administration of a seasonal or pandemic vaccine, with an effective amount of a synthetic or recombinant multimeric polypeptide comprising multiple copies of a plurality of influenza virus peptide epitopes.
A pharmaceutical composition comprising a synthetic or recombinant multimeric polypeptide comprising multiple copies of a plurality of influenza virus peptide epitopes, and at least one seasonal or pandemic preparation against influenza, and optionally containing a pharmaceutically acceptable adjuvant.
Dependencies are inferred from the claim text.