Prolactin receptor binding proteins and uses thereof

A binding protein capable of binding PRLR that competes with an antibody comprising a heavy chain variable domain and a light chain variable domain selected from the group consisting of:

• (1) a variable heavy chain having an amino acid sequence selected from the group consisting of SEQ ID NO:
• 39;
• SEQ ID NO:
• 43;
• SEQ ID NO:
• 44 and SEQ ID NO:
• 45;
• and a variable light chain having an amino acid sequence selected from the group consisting of SEQ ID NO:48, SEQ ID NO:52, SEQ ID NO:
• 53 and SEQ ID NO:54;
• (2) a variable heavy chain having an amino acid sequence selected from the group consisting of SEQ ID NO:
• 55;
• SEQ ID NO:
• 59;
• SEQ ID NO:
• 60 and SEQ ID NO:
• 61;
• and a variable light chain having an amino acid sequence selected from the group consisting of SEQ ID NO:64, SEQ ID NO:68 and SEQ ID NO:
• 69;
• (3) a variable heavy chain having an amino acid sequence selected from the group consisting of SEQ ID NO:
• 84;
• SEQ ID NO:
• 88;
• SEQ ID NO:
• 89;
• SEQ ID NO:
• 90;
• SEQ ID NO:
• 121;
• SEQ ID NO:
• 122;
• and SEQ ID NO:
• 123;
• and a variable light chain having an amino acid sequence selected from the group consisting of SEQ ID NO:91, SEQ ID NO:95 and SEQ ID NO:96;
• (4) the variable heavy chain amino acid sequence set forth in SEQ ID NO:112 and the variable light chain amino acid sequence set forth in SEQ ID NO:103;
• (5) the variable heavy chain amino acid sequence set forth in SEQ ID NO:113 and the variable light chain amino acid sequence set forth in SEQ ID NO:104;
• (6) the variable heavy chain amino acid sequence set forth in SEQ ID NO:114 and the variable light chain amino acid sequence set forth in SEQ ID NO:105;
• (7) the variable heavy chain amino acid sequence set forth in SEQ ID NO:116 and the variable light chain amino acid sequence set forth in SEQ ID NO:107;
• (8) the variable heavy chain amino acid sequence set forth in SEQ ID NO:117 and the variable light chain amino acid sequence set forth in SEQ ID NO:108;
• (9) the variable heavy chain amino acid sequence set forth in SEQ ID NO:118 and the variable light chain amino acid sequence set forth in SEQ ID NO:109;
• (10) the variable heavy chain amino acid sequence set forth in SEQ ID NO:119 and the variable light chain amino acid sequence set forth in SEQ ID NO:110;
• and
• (11) the variable heavy chain amino acid sequence set forth in SEQ ID NO:120 and the variable light chain amino acid sequence set forth in SEQ ID NO:111.

A binding protein capable of binding PRLR that

• (a) binds to an epitope in PRLR comprising three, four, five, six, seven, eight, nine or all of the amino acid residues E8, F10, C12, R25, E43, G44, I76, D91, E92, L93, Y94, V95, D96, Y99, I100, E145, F160, K185, D187, H188, Y190 and W191 of SEQ ID NO:2;
• (b) binds to an epitope in PRLR comprising three, four, five, six, seven, eight, nine or all of the amino acid residues E8, I9, F10, K11, C12, R25, E43, G44, W72, T74, I76, D91, E92, L93, Y94, V95, D96, T98, Y99, I100, W139, L143, E145, F160, K185, D187, H188, Y190 and W191 of SEQ ID NO:2;
• (c) binds to an epitope in PRLR comprising 13, 14, 15, 16, 17, 18, 19, 20, 21 or all of the amino acid residues R25, T141, L143, E145, R147, E155, W156, E157, I158, H159, F160, A161, G162, Q163, Q164, F167, S171, R183, K185, D187, H188, W191 and W194 of SEQ ID NO:2:
• (d) binds to an epitope in PRLR comprising at least one, two, three, four or all of the amino acid residues R25, K185, D187, H188 or W191 of SEQ ID NO:2;
• (e) binds to an epitope in PRLR comprising amino acids 91-96 of SEQ ID NO:2;
• (f) binds to an epitope having residues within at least amino acids 8-100, 185-191, 8-143, or 183-194 of SEQ ID NO:2;
• or
• (g) has the same epitopic specificity as an antibody, or antigen-binding portion thereof, selected from the group consisting of Ab1, Ab2, Ab3, Ab4, Ab5, chAb5, Ab6, chAb6, Ab7, chAb7, Ab8, chAb8, Ab9, chAb9, Ab10, chAb10, Ab11, chAb11, Ab12, chAb12, Ab13, chAb13, Ab14, Ab15, Ab16, Ab17, Ab18, Ab19, Ab20, Ab21, Ab22, Ab23, Ab24, Ab25, Ab26, Ab27, Ab28, Ab29, Ab30, Ab31, Ab32, Ab33, Ab34, Ab35, Ab36, Ab37, Ab38, Ab39, Ab40, Ab41, Ab42, Ab43, Ab44, Ab45, Ab46, Ab47, Ab48, Ab49, Ab50, Ab51, Ab52, Ab53, Ab54 and Ab55.