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US 2014/0227291 A1Published application
Amyloid-beta binding proteins
AssigneesAbbVie Deutschland GmbH & Co. KG, AbbVie Inc.
InventorsStefan Barghorn, Heinz Hillen, Andreas Striebinger, Simone Giasi, Ulrich Ebert, Chung-Ming Hsieh
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Abstract
The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
Claims54
A binding protein comprising six amino acid sequences which are at least 75% identical to the sequences forming a set of sequences selected from the set of sequences SEQ ID NOs:
- 17, 18, 19, 20, 21 and 22;
- and the set of sequences SEQ ID NOs:
- 33, 34, 35, 36, 37 and 38.
Dependencies are inferred from the claim text.