Pnmt as a novel marker for progenitor cells
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsSteven N. Ebert, Karl Pfeifer
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Abstract
In certain aspects, the present invention provides methods and compositions relating to a Pnmt-positive progenitor cell. In certain aspects, the present invention relates to methods for isolating and transplanting the subject progenitor cells, and methods for treating diseases such as myocardiac injuries and neurodegenerative disorders.
Claims15
A method of treating a subject for a myocardial injury, comprising introducing Phenylethanolamine N-methyltransferase (Pnmt)-positive cardiac progenitor cells into the subject, wherein the cardiac progenitor cells are committed to at least one cardiomyocyte specific lineage selected from the group consisting of a pacemaker cell, a His bundle (HIS) cell, a Purkinje fiber (PUR) cell, an atrial working myocyte, and a ventricular working myocyte.
Dependencies are inferred from the claim text.