Anti-pseudomonas psl binding molecules and uses thereof
AssigneeMedImmune, LLC
InventorsAntonio Digiandomenico, Paul G. Warrener, Charles K. Stover, Brett Sellman, Sandrine Gullard, Ralph Minter, Steven Rust, Mladen Tomich
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Abstract
The disclosure relates to an anti-Pseudomonas PSL binding molecule and uses thereof, in particular, in prevention and treatment of Pseudomonas infection. Furthermore, the disclosure provides compositions and methods for preventing and treating Pseudomonas infection.
Claims17
An isolated binding molecule, antibody or antigen-binding fragment thereof which specifically binds to Pseudomonas Psl, wherein the binding molecule (a) can inhibit attachment of Pseudomonas aeruginosa to epithelial cells, (b) can promote opsonophagocytic killing (OPK) of P. aeruginosa, or (c) can inhibit attachment of P. aeruginosa to epithelial cells and can promote OPK of P. aeruginosa.
2-85. (canceled)
Dependencies are inferred from the claim text.