Protein complex comprising mcm8 and mcm9 proteins and their use
AssigneeCentre National De La Recherche Scientifique
InventorsMarcel Mechali, Malik Lutzmann, Sabine Traver, Bernard De Massy, Corinne Grey
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Abstract
The composition includes either an isolated protein complex including MCM8 and MCM9 proteins, or nucleic acid molecules coding for the proteins that constitute the complex, or compounds inhibiting the formation and/or the stability, or the activity of the complex, for its use for enhancing or reducing animal, preferably mammal, fertility.
Claims15
1-17. (canceled)
An isolated non naturally occurring protein complex comprising MCM8 and MCM9 proteins, said complex being devoid of nucleic acid molecules, said MCM8 and MCM9 proteins being two distinct proteins.
A pharmaceutical composition comprising as active substance an isolated non naturally occurring protein complex comprising MCM8 and MCM9 proteins, said complex being devoid of nucleic acid molecules, said MCM8 and MCM9 proteins being two distinct proteins, in association with a pharmaceutically acceptable carrier.
A method for increasing animal fertility comprising administering an effective amount of an isolated non naturally occurring protein complex comprising MCM8 and MCM9 proteins, said complex being devoid of nucleic acid molecules, said MCM8 and MCM9 proteins being two distinct proteins.
A method for reducing animal fertility comprising administering an effective amount of a compound inhibiting the formation or the stability, or the formation and the stability, or the activity of a complex comprising MCM8 and MCM9 proteins, said MCM8 and MCM9 proteins being two distinct proteins,
- wherein said compound is chosen among antibodies, small inhibiting RNA, small hairpin RNA and antisense nucleic acid molecule.
A method for treating infertility comprising administering in an animal an effective amount of an isolated non naturally occurring protein complex comprising MCM8 and MCM9 proteins, said complex being devoid of nucleic acid molecules, said MCM8 and MCM9 proteins being two distinct proteins.
A method for the in vitro recombination of DNA or for the in vitro DNA repair, comprising a step of contacting a DNA molecule with an isolated non naturally occurring protein complex comprising MCM8 and MCM9 proteins, said complex being devoid of nucleic acid molecules, said MCM8 and MCM9 proteins being two distinct proteins.
Dependencies are inferred from the claim text.