Gpr177 as target and marker in tumors
AssigneesRuprecht-Karls-Universitaet Heidelberg, Deutsches Krebsforschungszentrum
InventorsMichael Boutros, Iris Augustin
Life of this patent
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Abstract
The present invention relates to modulators of G protein-coupled receptor 177 (Gpr177) for use in the treatment, alleviation, prevention and/or diagnosis of cancer as well as to methods for the diagnosis of such cancer.
Claims15
A modulator of G protein-coupled receptor 177 (Gpr177) for use in the treatment, alleviation, prevention and/or diagnosis of aberrant Wnt signaling, in particular cancer.
Method for diagnosing cancer, particularly breast and/or brain tumors, and/or for discrimination between cancerous and non-cancerous tissue, comprising the step of determining at least the expression of Gpr177 in a sample to be analyzed.
Pharmaceutical composition comprising at least one modulator, preferably inhibitor, of Gpr177.
Antibody against Gpr177 recognizing and/or binding
- (a) the epitope H-FTSPKTPEHEGRYYNC-OH
- (b) an epitope comprising at least 3 consecutive amino acids of a) but being N- or C-terminal shifted in the corresponding Gpr177 amino acid sequence or
- (c) an epitope having at least 75% amino acid identity to the epitopes of (a) and/or (b)
- or a corresponding antibody fragment.
A method of screening for an agent for the diagnosis, alleviation, treatment and/or prevention of aberrant Wnt signaling, in particular cancer, comprising the steps of
- (a) providing a cell capable of expressing G protein-coupled receptor 177 or/and providing a cell extract or sample, preferably brain or breast cell extract or sample, containing G protein-coupled receptor 177,
- (b) contacting a compound with the cell and/or the cell extract or sample,
- (c) determining the amount and/or the activity G protein-coupled receptor 177 and
- (d) selecting a compound which reduces the amount and/or activity of the G protein-coupled receptor 177.
Kit comprising at least an inhibitor of Gpr177, in particular an antibody against Gpr177.
Dependencies are inferred from the claim text.