Prevention and Treatment of Amyloidogenic Disease
AssigneeJanssen Alzheimer Immunotherapy
InventorDale B. Schenk
Life of this patent
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide, active fragments thereof or an antibody thereto.
Claims6
A method of preventing or treating a disease characterized by amyloid deposit in a patient, comprising administering an effective dosage of an antibody that specifically binds to the amyloid deposit or a component thereof to the patient.
2-37. (canceled)
A method of preventing or treating Alzheimer's disease, comprising administering an effective dosage of a polypeptide comprising an active fragment of Aβ that induces an immune response to Aβ in the patient.
39-52. (canceled)
A pharmaceutical composition comprising an active fragment of Aβ effective to induce a response to Aβ in a patient and an adjuvant.
54-163. (canceled)
Dependencies are inferred from the claim text.