Multi-specific binding molecules targeting aberrant cells
AssigneeApo-Tb.V.
InventorsRalph Alexander Willemsen, Johan Renes
Life of this patent
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Abstract
Described are proteinaceous molecules comprising at least two, preferably three to six, binding domains that bind specifically to at least two different binding sites on aberrant cells. These multi-domain and multi-specific binding molecules are preferably used in selectively modulating biological processes. The provided binding molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.
Claims20
A proteinaceous molecule comprising at least two different specific binding domains for different binding sites separated by at least one linker wherein said proteinaceous molecule comprises a single polypeptide chain.
(canceled)
A proteinaceous molecule according to FIG. 1 or FIG. 2.
A proteinaceous molecule comprising:
- at least two different specific binding domains for different binding sites separated by at least one linker,
- wherein at least one such binding domain is a Vh domain,
- wherein at least one such binding domain is a ligand for a receptor, and
- wherein the proteinaceous molecule comprises a single polypeptide chain.
Dependencies are inferred from the claim text.